Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tolazamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | GLA | P06280 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolazamide SCHEMBL13725632 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Tolazamide SCHEMBL34417 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Tolazamide SCHEMBL28562527 | 0.86 | ALDH1A1 (0.97) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| SCHEMBL5820456 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Gliclazide SCHEMBL6344915 | 0.78 | ALDH1A1 (0.88) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Tolazamide SCHEMBL992662 | 0.76 | ALDH1A1 (0.75) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Tolbutamide SCHEMBL27504620 | 0.74 | ALDH1A1 (0.77) | ALDH1A1CYP3A4MAPTNFKB1LMNA | |
| Ly-181984 SCHEMBL6368379 | 0.74 | CA12 (0.62) | ALDH1A1TP53MAPTLMNATSHR | |
| Glypinamide SCHEMBL343885 | 0.74 | ALDH1A1 (0.74) | ALDH1A1KDM4ETP53GLACYP3A4 | |
| Tolazamide SCHEMBL2534564 | 0.73 | ALDH1A1 (0.70) | ALDH1A1KDM4ETP53GLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101675036-A | Dual-effect benzimidazole antihypertensive agents | THERAVANCE INC | 2010-03-17 | — | — | CN | disclosed |