SCHEMBL1372596

SCHEMBL1372596

O=[N+]([O-])c1ccc2ccn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
THRB P10828 1/20 0.48
MTOR P42345 1/20 0.48
MDM2 Q00987 1/20 0.48
NCOA1 Q15788 1/20 0.48
NCOA3 Q9Y6Q9 1/20 0.48
SLC29A1 Q99808 10/20 0.48
SLC28A1 O00337 1/20 0.47
SLC28A2 O43868 1/20 0.47
SLC28A3 Q9HAS3 1/20 0.47
ADORA3 P0DMS8 1/20 0.47
CYP1A2 P05177 1/20 0.46
NFKB1 P19838 1/20 0.46
THPO P40225 1/20 0.46
ALDH1A1 P00352 1/20 0.46
PMP22 Q01453 1/20 0.46
RAB9A P51151 1/20 0.46
CYP3A4 P08684 1/20 0.46
PKM P14618 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30356 1.00 LMNA (0.48) LMNATHRBMTORMDM2NCOA1
SCHEMBL14534827 0.92 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL14084325 0.92 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL1062447 0.92 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL29703 0.92 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL29446054 0.92 LMNA (0.49) LMNATHRBMTORMDM2NCOA1
SCHEMBL11934657 0.83 SLC29A1 (0.42) LMNATHRBMTORMDM2NCOA1
SCHEMBL11934656 0.83 SLC29A1 (0.42) LMNATHRBMTORMDM2NCOA1
SCHEMBL650683 0.79 CYP1A2 (0.42) SLC29A1ADORA3CYP1A2NFKB1THPO
SCHEMBL1777532 0.78 LMNA (0.49) LMNATHRBMTORMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100015708-A1 RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF MDRNA, INC. (US) 2010-01-21 US claimed
EP-3372684-B1 SINGLE-STRANDED RNAI AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER SIRNA THERAPEUTICS INC (US) 2020-10-07 EP disclosed
US-10584335-B2 Single-stranded RNAi agents containing an internal, non-nucleic acid spacer SIRNA THERAPEUTICS, INC. (US) 2020-03-10 US disclosed
US-20200056224-A1 BARCODED TRANSPOSASES TO INCREASE EFFICIENCY OF HIGH-ACCURACY GENETIC SEQUENCING FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2020-02-20 US disclosed
EP-2341943-B1 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA POSSESSING MODIFICATIONS DICERNA PHARMACEUTICALS INC (US) 2018-11-07 EP disclosed
WO-2018195224-A1 BARCODED TRANSPOSASES TO INCREASE EFFICIENCY OF HIGH-ACCURACY GENETIC SEQUENCING FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2018-10-25 WO disclosed
EP-3372684-A1 SINGLE-STRANDED RNAI AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER Sirna Therapeutics, Inc. (US) 2018-09-12 EP disclosed
US-10023863-B2 Therapeutics with conformationally restricted monomers MARINA BIOTECH, INC. (US) 2018-07-17 US disclosed
US-20180119214-A1 COMPOSITIONS AND METHODS FOR TARGET NUCLEIC ACID MOLECULE ENRICHMENT FRED HUTCHINSON CANCER RESEARCH CENTER 2018-05-03 US disclosed
US-20180112216-A1 SEGMENTED MICRO RNA MIMETICS BANK OF AMERICA, N.A. 2018-04-26 US disclosed
WO-2008109500-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING PRKCA GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109474-A1 NUCLEIC ACID COMPOUNDS FOR INHIBITING FGF2 GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109470-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING PTPN1 GENE EXPRESSION AND USES THEREOF NASTECH PHARMACEUTICAL COMPANY INC. (US) 2008-09-12 WO disclosed
WO-2008109516-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING RAS GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109520-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING CXC GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109558-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING TLR GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109475-A1 NUCLEIC ACID COMPOUNDS FOR INHIBITING SIRT2 GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109492-A1 NUCLEIC ACID COMPOUNDS FOR INHIBITING IGF1R GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008109366-A2 NUCLEIC ACID COMPOUNDS FOR INHIBITING CCND1 GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
US-20080076701-A1 DICER SUBSTRATE RNA PEPTIDE CONJUGATES AND METHODS FOR RNA THERAPEUTICS NASTECH PHARMACEUTICAL COMPANY INC. (US) 2008-03-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080076701-A1 DICER SUBSTRATE RNA PEPTIDE CONJUGATES AND METHODS FOR RNA THERAPEUTICS RNASE1, SARNP, AGO2 LMNA 1631/4885THRB 2819/4885MTOR 4123/4885
US-20100015708-A1 RIBONUCLEIC ACIDS WITH NON-STANDARD BASES AND USES THEREOF NSUN2, NSUN3, RNMT LMNA 1906/4885THRB 3912/4885MTOR 4225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.