Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11501545 | 0.85 | MEN1 (0.46) | NPC1ALOX15LMNAGBA1TP53 | |
| SCHEMBL11668286 | 0.85 | TSHR (0.49) | NPC1ALOX15LMNAGBA1TP53 | |
| SCHEMBL11668321 | 0.85 | TSHR (0.49) | NPC1ALOX15LMNAGBA1TP53 | |
| SCHEMBL11501626 | 0.85 | TSHR (0.49) | NPC1ALOX15LMNAGBA1TP53 | |
| SCHEMBL29748200 | 0.80 | GBA1 (0.32) | ALOX15LMNAGBA1TP53CYP3A4 | |
| SCHEMBL11501927 | 0.75 | TSHR (0.51) | NPC1ALOX15LMNATP53TSHR | |
| SCHEMBL14868758 | 0.73 | TSHR (0.49) | NPC1ALOX15LMNATSHRHTT | |
| SCHEMBL11501940 | 0.72 | CACNA1G (0.50) | TP53CNR1SIGMAR1 | |
| SCHEMBL11070209 | 0.71 | MEN1 (0.47) | NPC1ALOX15LMNAGBA1TP53 | |
| SCHEMBL11501785 | 0.71 | TSHR (0.54) | NPC1ALOX15LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2705390-A1 | MEDICAL DEVICES HAVING HOMOGENEOUS CHARGE DENSITY AND METHODS FOR MAKING SAME | Johnson & Johnson Vision Care Inc. (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012151135-A1 | MEDICAL DEVICES HAVING HOMOGENEOUS CHARGE DENSITY AND METHODS FOR MAKING SAME | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2012-11-08 | — | — | WO | disclosed |