Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PRKX | P51817 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13728788 | 0.89 | MMP13 (0.62) | PRMT6MMP13HTTSMN1; SMN2P2RX7 | |
| SCHEMBL13728272 | 0.88 | PRMT6 (0.50) | ROCK2ROCK1AURKAPRMT6MMP13 | |
| SCHEMBL27965276 | 0.82 | MMP13 (0.69) | ROCK2ROCK1MMP13CYP2D6PRKACA | |
| SCHEMBL27913945 | 0.80 | MEN1 (0.59) | ROCK2MMP13CYP3A4CYP2D6 | |
| SCHEMBL5252907 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1AURKAMMP13CYP3A4 | |
| SCHEMBL22501609 | 0.79 | PRMT6 (0.62) | ROCK2ROCK1AURKAPRMT6MMP13 | |
| SCHEMBL13729601 | 0.79 | FFAR1 (0.56) | ROCK2ROCK1MMP13CYP3A4CYP2D6 | |
| SCHEMBL13728048 | 0.79 | MMP13 (0.77) | MMP13MAPK1HTTSMN1; SMN2P2RX7 | |
| SCHEMBL13729131 | 0.78 | MMP13 (0.52) | MMP13CYP2C9MAPK1HTTSMN1; SMN2 | |
| SCHEMBL27931805 | 0.77 | ROCK2 (0.66) | ROCK2ROCK1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |