Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643583 | 0.73 | KDM4E (0.41) | TSHRCYP2D6CYP2C19HIF1AKDM4E | |
| SCHEMBL27906618 | 0.73 | TSHR (0.42) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL997630 | 0.72 | ALDH1A1 (0.37) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL2775453 | 0.72 | FDPS (0.37) | TSHRALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL1126526 | 0.71 | ADRA1A (0.48) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 | |
| SCHEMBL28253558 | 0.70 | MEN1 (0.35) | TSHRCYP2C19ALDH1A1KDM4ELMNA | |
| SCHEMBL364358 | 0.70 | MEN1 (0.35) | TSHRCYP2C19ALDH1A1KDM4ELMNA | |
| SCHEMBL3871128 | 0.70 | FFAR3 (0.36) | TSHRCYP2D6CYP2C19HIF1AKDM4E | |
| SCHEMBL9451184 | 0.70 | FFAR3 (0.36) | TSHRCYP2C19KDM4ELMNAALOX15 | |
| SCHEMBL7611993 | 0.69 | TSHR (0.36) | TSHRCYP2D6CYP2C19HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704793-A1 | REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Ramot at Tel Aviv University, Ltd. (IL) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012150600-A2 | REGULATION OF AMYLOID BETA MOLECULAR COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-11-08 | — | — | WO | disclosed |