Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10008764 | 0.80 | PKLR (0.75) | PKLRPKMMEN1KMT2A | |
| SCHEMBL16049821 | 0.79 | PKLR (0.69) | PKLR | |
| SCHEMBL12476933 | 0.78 | PKLR (0.45) | PKLRPKMHTR6MEN1KMT2A | |
| SCHEMBL10009388 | 0.77 | PKLR (0.71) | PKLRPKMMEN1KMT2A | |
| SCHEMBL10008927 | 0.75 | PKLR (0.68) | PKLRPKMMEN1KMT2A | |
| SCHEMBL20750615 | 0.73 | CCR2 (0.49) | KCNH2CCR2TP53PIK3CAMTOR | |
| SCHEMBL16049789 | 0.72 | PKLR (0.70) | PKLR | |
| SCHEMBL10008244 | 0.72 | PKLR (0.64) | PKLRPKMMEN1KMT2A | |
| SCHEMBL6690559 | 0.72 | HTR6 (0.45) | PKLRPKMHTR6MEN1KMT2A | |
| SCHEMBL20036185 | 0.71 | PKLR (0.44) | PKLRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704720-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | Agios Pharmaceuticals, Inc. (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012151452-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS, INC (US) | 2012-11-08 | — | — | WO | disclosed |