Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15772590 | 0.86 | CTSS (0.37) | KMT2AJAK2 | |
| SCHEMBL15772589 | 0.86 | CTSS (0.37) | KMT2AJAK2 | |
| SCHEMBL13734135 | 0.81 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2ACNR2 | |
| SCHEMBL13728858 | 0.78 | SMN1; SMN2 (0.41) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL15956851 | 0.77 | CYP2C9 (0.37) | NPC1RAB9ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15771740 | 0.77 | ALDH1A1 (0.47) | NPC1MEN1KMT2ACNR2 | |
| SCHEMBL15772229 | 0.76 | ANPEP (0.33) | — | |
| SCHEMBL13731696 | 0.76 | RAB9A (0.46) | NPC1RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL13728974 | 0.76 | POLB (0.41) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13730317 | 0.76 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340547-B2 | Pyrrolotriazinone derivatives as inhibitors P13K | ALMIRALL, S.A. (ES) | 2016-05-17 | — | — | US | disclosed |
| EP-2702061-B9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2016-02-24 | — | — | EP | disclosed |
| EP-2702061-B1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2015-07-29 | — | — | EP | disclosed |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, SA (ES) | 2015-04-09 | — | — | US | disclosed |
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | ALMIRALL, SA (ES) | 2014-06-12 | — | — | US | disclosed |
| EP-2702061-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | Almirall S.A. (ES) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012146666-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, S.A. (ES) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | PIP4K2B, PDPK1, PI4KA | ACACB 2569/4885NPC1 2267/4885RAB9A 1661/4885 |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | PIK3CD, PIK3CA, PIK3CB | ACACB 1723/4885NPC1 2289/4885RAB9A 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.