Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRE | P78334 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918137 | 0.84 | NOD1 (0.39) | ALDH1A1ENPEPDPP4DPP8DPP9 | |
| SCHEMBL3987945 | 0.83 | GRM8 (0.42) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3850920 | 0.83 | GRM8 (0.42) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL622765 | 0.83 | GRM8 (0.42) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5964600 | 0.83 | GRM8 (0.42) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL660692 | 0.81 | NOD1 (0.49) | NAALAD2 | |
| SCHEMBL1249331 | 0.81 | NOD1 (0.49) | NAALAD2 | |
| SCHEMBL3213831 | 0.80 | ADRA1A (0.43) | ALDH1A1MEN1CYP1A2THRBKMT2A | |
| SCHEMBL15401429 | 0.80 | NOD1 (0.51) | ALDH1A1DPP4DPP8DPP9 | |
| SCHEMBL15542060 | 0.80 | BLM (0.41) | ALDH1A1CYP1A2KMT2ALMNAENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1774017-B1 | PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING | PFENEX INC (US) | 2013-05-15 | — | — | EP | claimed |
| US-10689640-B2 | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins | PFENEX INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20170183646-A1 | METHOD FOR RAPIDLY SCREENING MICROBIAL HOSTS TO IDENTIFY CERTAIN STRAINS WITH IMPROVED YIELD AND/OR QUALITY IN THE EXPRESSION OF HETEROLOGOUS PROTEINS | PELICAN TECHNOLOGY HOLDINGS, INC. | 2017-06-29 | — | — | US | disclosed |
| US-9580719-B2 | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins | PFENEX, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-9394571-B2 | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins | PFENEX INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-8906636-B2 | High level expression of recombinant toxin proteins | PFENEX INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140051093-A1 | HIGH LEVEL EXPRESSION OF RECOMBINANT TOXIN PROTEINS | PFENEX INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8530171-B2 | High level expression of recombinant toxin proteins | PFENEX INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110287443-A1 | HIGH LEVEL EXPRESSION OF RECOMBINANT TOXIN PROTEINS | PFENEX INC. (US) | 2011-11-24 | — | — | US | disclosed |
| WO-2011123139-A1 | HIGH LEVEL EXPRESSION OF RECOMBINANT CRM197 | PFENEX, INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20100137162-A1 | Method for Rapidly Screening Microbial Hosts to Identify Certain Strains with Improved Yield and/or Quality in the Expression of Heterologous Proteins | PFENEX BIOPHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2142651-A2 | METHOD FOR RAPIDLY SCREENING MICROBIAL HOSTS TO IDENTIFY CERTAIN STRAINS WITH IMPROVED YIELD AND/OR QUALITY IN THE EXPRESSION OF HETEROLOGOUS PROTEINS | Dow Global Technologies Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008134461-A2 | METHOD FOR RAPIDLY SCREENING MICROBIAL HOSTS TO IDENTIFY CERTAIN STRAINS WITH IMPROVED YIELD AND/OR QUALITY IN THE EXPRESSION OF HETEROLOGOUS PROTEINS | DOW GLOBAL TECHNOLOGIES, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20080269070-A1 | METHOD FOR RAPIDLY SCREENING MICROBIAL HOSTS TO IDENTIFY CERTAIN STRAINS WITH IMPROVED YIELD AND/OR QUALITY IN THE EXPRESSION OF HETEROLOGOUS PROTEINS | DOW GLOBAL TECHNOLOGIES, INC. (US) | 2008-10-30 | — | — | US | disclosed |