Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439989 | 0.79 | BACE1 (0.38) | MAPTPOLBSLC9A1KEAP1HRH4 | |
| SCHEMBL2914480 | 0.71 | MAPT (0.46) | MAPTACHEPOLBKMT2AHTT | |
| SCHEMBL14416828 | 0.69 | HRH4 (0.42) | MAPTPOLBTLR8PARP1ELANE | |
| SCHEMBL590272 | 0.69 | KDR (0.43) | MAPTTLR8KMT2ACD44MEN1 | |
| SCHEMBL9138367 | 0.65 | GRM4 (0.46) | MAPTTLR8HTTSLC9A1KEAP1 | |
| SCHEMBL16506376 | 0.65 | PDE10A (0.38) | SLC9A1KEAP1NPC1RAB9A | |
| SCHEMBL13106159 | 0.65 | PARP1 (0.41) | PARP1ELANESLC9A1KEAP1 | |
| SCHEMBL11627568 | 0.65 | ELANE (0.45) | ACHEPARP1ELANE | |
| SCHEMBL29059152 | 0.65 | KAT2B (0.47) | — | |
| SCHEMBL12536276 | 0.64 | MAPK13 (0.42) | MAPTKMT2AHTTSLC9A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103910716-A | 2,4-disubstituted-cycloalkyl[d]pyrimidine compound and its use | UNIV EAST CHINA SCIENCE & TECH | 2014-07-09 | — | — | CN | disclosed |
| CN-103739550-A | 2, 3-dimethyl-6-urea-2H-indazole compound and preparation method and application thereof | UNIV CHINA PHARMA | 2014-04-23 | — | — | CN | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| CN-101370505-B | Treatment of ocular neovascular disorders such as macular degeneration, angioid streaks, uveitis and macular edema | SMITHKLINE BEECHAM CORP | 2012-03-21 | — | — | CN | disclosed |
| CN-101370505-A | Treatment of ocular neovascular disorders such as macular degeneration, angioid streaks, uveitis and macular edema | SMITHKLINE BEECHAM CORP (US) | 2009-02-18 | — | — | CN | disclosed |
| CN-1307173-C | Pyrimidinamines as angiogenesis modulators | GLAXO GROUP LTD (GB) | 2007-03-28 | — | — | CN | disclosed |
| CN-1688553-A | Chemical process | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | CN | disclosed |
| CN-1549813-A | Pyrimidinamines as angiogenesis modulators | — | 2004-11-24 | — | — | CN | disclosed |