Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30474592 | 0.82 | PRMT5 (0.41) | PARP1PSMB8PRMT5MAOBHSD11B1 | |
| SCHEMBL16506376 | 0.77 | PDE10A (0.38) | CHRM4HSD11B1XIAPBIRC2SLC9A1 | |
| SCHEMBL13106183 | 0.76 | HSD11B1 (0.37) | CHRM4HSD11B1 | |
| SCHEMBL13106238 | 0.73 | NR4A2 (0.42) | PARP1HSD11B1GAACRHR1DHODH | |
| SCHEMBL13106169 | 0.73 | HSD11B1 (0.41) | CHRM4HSD11B1GAANR1H2NR1H3 | |
| SCHEMBL8538654 | 0.73 | PRMT5 (0.37) | PARP1PRMT5MAOB | |
| Lithium Ion SCHEMBL8540488 | 0.72 | PARP1 (0.35) | PARP1PSMB8PRMT5MAOBELANE | |
| SCHEMBL21631687 | 0.70 | CHRM4 (0.38) | CHRM4 | |
| SCHEMBL13106161 | 0.69 | NR3C1 (0.41) | HSD11B1GAA | |
| SCHEMBL13106192 | 0.69 | MAPT (0.34) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110028495-B | The preparation method of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-12-03 | — | — | CN | claimed |
| CN-110028495-A | The environment-friendly preparation method thereof of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-07-19 | — | — | CN | claimed |
| CN-110028495-B | The preparation method of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-12-03 | — | — | CN | disclosed |
| CN-110028495-A | The environment-friendly preparation method thereof of pazopanib hydrochloride | 济南爱思医药科技有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-103450085-A | Preparation method of pazopanib hydrochloride key intermediate | ASYMCHEM LAB TIANJIN CO LTD | 2013-12-18 | — | — | CN | disclosed |
| US-7812045-B2 | Antifungal triazole derivatives | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2010-10-12 | — | — | US | disclosed |
| US-20080194661-A1 | Antifungal Triazole Derivatives | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194661-A1 | Antifungal Triazole Derivatives | ERG28, CYP51A1, CYP3A43 | PARP1 2201/4885PSMB8 1955/4885PRMT5 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.