Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732339 | 0.82 | ATM (0.39) | KLK7KLK5NR1H2MAPTKDM4E | |
| SCHEMBL3398097 | 0.80 | CHRM2 (0.37) | KLK7KLK5NR1H2MMP3ADAM17 | |
| SCHEMBL13731951 | 0.78 | NR1H2 (0.33) | KLK7KLK5NR1H2MAPTKDM4E | |
| SCHEMBL581822 | 0.75 | CHRM2 (0.34) | KLK7KLK5NR1H2MMP3ADAM17 | |
| SCHEMBL5573878 | 0.73 | MAPT (0.40) | MMP3ADAM17MAPTKDM4ETHRB | |
| SCHEMBL5573872 | 0.73 | MAPT (0.40) | MMP3ADAM17MAPTKDM4ETHRB | |
| SCHEMBL24364010 | 0.72 | NR1H2 (0.35) | KLK7KLK5NR1H2MMP3ADAM17 | |
| SCHEMBL4774639 | 0.72 | MME (0.38) | KLK7KLK5NR1H2MMP3ADAM17 | |
| SCHEMBL8021097 | 0.71 | CHRM2 (0.42) | KLK7KLK5NR1H2MMP3ADAM17 | |
| SCHEMBL29060412 | 0.71 | MMP3 (0.37) | NR1H2MMP3ADAM17MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699581-B1 | 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2015-11-25 | — | — | EP | disclosed |
| US-8957218-B2 | 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives | UCB PHARMA S.A. (BE) | 2015-02-17 | — | — | US | disclosed |
| US-20140148489-A1 | 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives | UCB PHARMA, S.A. (BE) | 2014-05-29 | — | — | US | disclosed |
| EP-2699581-A1 | 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB Pharma, S.A. (BE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143117-A1 | 2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES | UCB PHARMA, S.A. (BE) | 2012-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148489-A1 | 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives | CYP3A4, CYP3A43, CYP3A7 | KLK7 3304/4885KLK5 2339/4885NR1H2 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.