Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | KHK | P50053 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734733 | 0.85 | NPC1 (0.56) | KHKKDM4ESMN1; SMN2GAAMAPT | |
| SCHEMBL13735876 | 0.83 | PTGS2 (0.56) | SMN1; SMN2MAPTNPC1ALDH1A1PTGS2 | |
| SCHEMBL28809680 | 0.81 | PTGS2 (0.58) | SMN1; SMN2MAPTNPC1ALDH1A1PTGS2 | |
| SCHEMBL13736967 | 0.81 | PTGS2 (0.60) | KDM4ESMN1; SMN2GAAMAPTNPC1 | |
| SCHEMBL12319455 | 0.79 | CHRNA7 (0.79) | CHRNA7KDM4ERAD52SMN1; SMN2GAA | |
| SCHEMBL5907310 | 0.76 | MAPK9 (0.56) | NPC1ALDH1A1PTGS2MEN1KMT2A | |
| SCHEMBL1155787 | 0.75 | MDM2 (0.55) | NPC1ALDH1A1PTGS2RAB9A | |
| SCHEMBL1101883 | 0.75 | CHRNA7 (1.00) | CHRNA7KDM4ERAD52SMN1; SMN2GAA | |
| SCHEMBL12759885 | 0.75 | MDM2 (0.52) | MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL28903831 | 0.74 | MAP4K1 (0.48) | CHRNA7KDM4ESMN1; SMN2SMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |