Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.71 |
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | GFER | P55789 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | RAD52 | P43351 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11555541 | 0.98 | CHRNA7 (0.96) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| SCHEMBL15304372 | 0.92 | CHRNA7 (0.85) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| Isothiocyanate SCHEMBL2895505 | 0.89 | CHRNA7 (0.79) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| SCHEMBL12319455 | 0.88 | CHRNA7 (0.79) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| SCHEMBL28852004 | 0.88 | CHRNA7 (0.78) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| SCHEMBL12319831 | 0.84 | CHRNA7 (0.71) | CHRNA7SIGMAR1DRD2KDM4EMAPT | |
| SCHEMBL3453669 | 0.83 | DRD2 (1.00) | CHRNA7SIGMAR1DRD2DRD4KCNH2 | |
| SCHEMBL9041083 | 0.82 | KCNH2 (0.80) | CHRNA7SIGMAR1DRD2DRD4KCNH2 | |
| SCHEMBL81930 | 0.81 | GAA (0.69) | CHRNA7KDM4EMAPTGFERGAA | |
| SCHEMBL576454 | 0.81 | LMNA (0.67) | CHRNA7SIGMAR1DRD2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048405-A | Aryl-substituted piperazine derivatives | NEUROGEN CORP (US) | 2007-10-03 | — | — | CN | claimed |
| CN-1257896-C | Funcitonal molecule material containing four tertiary amine branches and preparation method | UNIV FUDAN (CN) | 2006-05-31 | — | — | CN | claimed |
| CN-1539833-A | Funcitonal molecule material containing four tertiary amine branches and preparation method | 复旦大学 | 2004-10-27 | — | — | CN | claimed |
| EP-0548798-A1 | Antiviral agent | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1993-06-30 | — | — | EP | claimed |
| US-20230365582-A1 | NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF | KANAPH THERAPEUTICS INC. (KR) | 2023-11-16 | — | — | US | disclosed |
| US-20230346797-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-11-02 | — | — | US | disclosed |
| CN-116848107-A | Compounds and their use as PDE4 activators | 米罗尼德有限公司 | 2023-10-03 | — | — | CN | disclosed |
| WO-2023158221-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING ANTICANCER AGENT AND NOVEL COMPOUND HAVING INHIBITORY ACTIVITY WITH RESPECT TO PROSTAGLANDIN E2 RECEPTORS | 주식회사 카나프테라퓨틱스 | 2023-08-24 | — | — | WO | disclosed |
| US-20230002383-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | PRAEVENTIX, LLC | 2023-01-05 | — | — | US | disclosed |
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (FR) | 2022-12-08 | — | — | US | disclosed |
| US-20220393117-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | UNIVERSAL DISPLAY CORPORATION (US) | 2022-12-08 | — | — | US | disclosed |
| EP-2696873-B1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | US HEALTH (US) | 2022-08-03 | — | — | EP | disclosed |
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0548798-A1 | Antiviral agent | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |
| US-4668681-A | ANTIALLERGENS, ANAPHYLAXIS, MOTION SICKNESS | SOCIETE CORTIAL, S.A. (FR) | 1987-05-26 | — | — | US | disclosed |
| EP-0078756-B1 | 2-(4-PHENYL-PIPERAZINYLETHYL) ANILINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINE | CORTIAL S.A. (FR) | 1986-03-12 | — | — | EP | disclosed |
| EP-0078757-B1 | IMINES OF 2-(4-PHENYL-PIPERAZINYLETHYL) ANILINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINE | CORTIAL S.A. (FR) | 1985-09-04 | — | — | EP | disclosed |
| EP-0078756-A1 | 2-(4-Phenyl-piperazinylethyl) anilines, process for their preparation and their use in medicine | CORTIAL S.A. (FR) | 1983-05-11 | — | — | EP | disclosed |
| EP-0078757-A1 | Imines of 2-(4-phenyl-piperazinylethyl) anilines, process for their preparation and their use in medicine | CORTIAL S.A. (FR) | 1983-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220393117-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | NPY1R, NPY2R, KISS1R | CHRNA7 1524/4885SIGMAR1 776/4885DRD2 1670/4885 |
| US-20230346797-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | SLC8B1, CATSPER1, SLC9A1 | CHRNA7 2723/4885SIGMAR1 1844/4885DRD2 4270/4885 |
| US-20230365582-A1 | NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF | PTGER1, PTGIR, PTGDR2 | CHRNA7 2115/4885SIGMAR1 420/4885DRD2 2570/4885 |
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | HTT, NTRK2, BDNF | CHRNA7 60/4885SIGMAR1 1243/4885DRD2 1688/4885 |
| US-20230002383-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | HTR7, HTR1A, HTR2C | CHRNA7 40/4885SIGMAR1 38/4885DRD2 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.