Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732305 | 1.00 | PKM (0.36) | PKMRXFP1BRD4MAPK1ATM | |
| SCHEMBL13736015 | 1.00 | PKM (0.36) | PKMRXFP1BRD4MAPK1ATM | |
| SCHEMBL13734073 | 0.85 | TGFBR1 (0.36) | PKMBRD4MAPK1ATMKDM4E | |
| SCHEMBL13735175 | 0.83 | RXFP1 (0.36) | PKMRXFP1BRD4KDM4ELMNA | |
| SCHEMBL4734703 | 0.73 | BRD4 (0.38) | RXFP1BRD4KDM4ESMN1; SMN2PTGS1 | |
| SCHEMBL4734075 | 0.72 | BRD4 (0.57) | PKMBRD4LMNA | |
| SCHEMBL4733870 | 0.72 | NOTUM (0.42) | RXFP1BRD4LMNAL3MBTL1 | |
| SCHEMBL13733079 | 0.72 | RXFP1 (0.39) | RXFP1KDM4ESMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL2360506 | 0.71 | BRD4 (0.47) | BRD4SMN1; SMN2 | |
| SCHEMBL13363565 | 0.70 | BRD4 (0.46) | BRD4ATMKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699561-B1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORP (FI) | 2015-06-03 | — | — | EP | disclosed |
| US-8921378-B2 | Androgen receptor modulating carboxamides | ORION CORPORATION (FI) | 2014-12-30 | — | — | US | disclosed |
| EP-2699561-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | Orion Corporation (FI) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143599-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORPORATION (FI) | 2012-10-26 | — | — | WO | disclosed |