Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 9/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.41 |
| ▸ | PTPRC | P08575 | 3/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | PTPN9 | P43378 | 3/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.41 |
| ▸ | EPM2A | O95278 | 2/20 | 0.39 |
| ▸ | PTPRG | P23470 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.39 |
| ▸ | PTPN13 | Q12923 | 2/20 | 0.39 |
| ▸ | DUSP22 | Q9NRW4 | 2/20 | 0.39 |
| ▸ | CDC14A | Q9UNH5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735852 | 0.92 | PTPN22 (0.45) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13736592 | 0.92 | PTPN11 (0.49) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13736534 | 0.91 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13737903 | 0.87 | L3MBTL1 (0.42) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13739517 | 0.86 | PTPN22 (0.54) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13738214 | 0.86 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL15829161 | 0.83 | PTPN11 (0.41) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13738188 | 0.83 | PTPN11 (0.44) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13738019 | 0.79 | PTPN11 (0.48) | L3MBTL1ALDH1A1GLAHPGDTDP1 | |
| SCHEMBL13737481 | 0.78 | PTPN11 (0.54) | L3MBTL1ALDH1A1GLAHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140179735-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION | 2014-06-26 | — | — | US | disclosed |
| CN-103561573-A | Tyrosine phosphatases and their use in modulating the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | UNIV INDIANA RES & TECH CORP | 2014-02-05 | — | — | CN | disclosed |
| WO-2012149048-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF LYP | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012149049-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMES INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179735-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | PPP3CB, PPP4C, PTPRB | L3MBTL1 2441/4885ALDH1A1 803/4885GLA 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.