Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28246290 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL3821799 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL1221462 | 0.78 | SLC6A2 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL2875169 | 0.75 | SLC6A2 (0.41) | L3MBTL1LMNASLC6A2SLC6A4 | |
| SCHEMBL17786300 | 0.75 | SLC6A2 (0.41) | L3MBTL1LMNASLC6A2SLC6A4 | |
| SCHEMBL1612684 | 0.75 | L3MBTL1 (0.39) | L3MBTL1SIGMAR1CYP3A4ALDH1A1LMNA | |
| SCHEMBL2304116 | 0.74 | SIGMAR1 (0.39) | L3MBTL1SIGMAR1CYP3A4ALDH1A1LMNA | |
| SCHEMBL3818321 | 0.73 | SLC6A4 (0.44) | L3MBTL1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL22236152 | 0.73 | L3MBTL1 (0.35) | L3MBTL1SIGMAR1KDM5AKDM4CCTSD | |
| SCHEMBL18704813 | 0.73 | SLC6A2 (0.46) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702063-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012148775-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-11-01 | — | — | WO | disclosed |