Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 12/20 | 0.41 |
| ▸ | SKP1 | P63208 | 12/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 12/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13556491 | 0.83 | CKS1B (0.55) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL19489712 | 0.81 | MAP4K4 (0.39) | SIRT2SIRT1SIRT3LOXL2CHEK1 | |
| SCHEMBL13736221 | 0.80 | PIM1 (0.44) | SIRT2SIRT1SIRT3HPGD | |
| SCHEMBL13736218 | 0.80 | PIM1 (0.44) | SIRT2SIRT1SIRT3HPGD | |
| SCHEMBL1729041 | 0.79 | NPC1 (0.55) | CKS1BSKP1SKP2TSHR | |
| SCHEMBL1728003 | 0.77 | CD38 (0.43) | CKS1BSKP1SKP2TSHRHSD17B10 | |
| SCHEMBL27920414 | 0.76 | GPR119 (0.48) | CKS1BSKP1SKP2 | |
| SCHEMBL13387983 | 0.76 | HRH4 (0.35) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL29931619 | 0.76 | DKK1 (0.49) | CKS1BSKP1SKP2KDM4EALDH1A1 | |
| SCHEMBL1774210 | 0.76 | LOXL2 (0.41) | CKS1BSKP1SKP2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699569-B1 | AMINOPYRIMIDINE KINASE INHIBITORS | JASCO PHARMACEUTICALS LLC (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2699569-A2 | AMINOPYRIMIDINE KINASE INHIBITORS | Jasco Pharmaceuticals LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012145617-A9 | AMINOPYRIMIDINE KINASE INHIBITORS | Jasco Pharmaceuticals, LLC (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2012145617-A2 | AMINOPYRIMIDINE KINASE INHIBITORS | Jasco Pharmaceuticals, LLC (US) | 2012-10-26 | — | — | WO | disclosed |