Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907145 | 0.78 | PDE10A (0.37) | PDE10A | |
| SCHEMBL13736655 | 0.77 | ADCY10 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL16695052 | 0.76 | MEN1 (0.45) | PDE10AALDH1A1KDM4EGUCY1A1GUCY1B1 | |
| SCHEMBL14048225 | 0.74 | PDE10A (0.46) | PDE10AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13739532 | 0.71 | GUCY1A1 (0.48) | ALDH1A1KDM4EGUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL19480652 | 0.70 | GUCY1A1 (0.46) | ALDH1A1KDM4EGUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL13738365 | 0.69 | GUCY1A1 (0.46) | ALDH1A1KDM4EGUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL7896683 | 0.68 | MAPT (0.42) | KDM4EKCNH2MAPTHTT | |
| SCHEMBL7904953 | 0.68 | HAO1 (0.38) | PDE10ANPC1 | |
| SCHEMBL20140256 | 0.68 | PDE10A (0.42) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751106-B1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER IP GMBH (DE) | 2017-10-18 | — | — | EP | disclosed |
| EP-2822951-B1 | SUBSTITUTED AZABICYCLES AND USE THEREOF | BAYER IP GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |
| EP-2822951-B1 | SUBSTITUTED AZABICYCLES AND USE THEREOF | BAYER IP GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |
| US-9498480-B2 | Substituted azabicycles and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9498480-B2 | Substituted azabicycles and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9498480-B2 | Substituted azabicycles and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| EP-2705037-B1 | SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND USE THEREOF | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| EP-2705037-B1 | SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND USE THEREOF | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| US-9150580-B2 | Substituted imidazopyridines and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9150580-B2 | Substituted imidazopyridines and the use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-20140113900-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-24 | — | — | US | disclosed |
| US-20140113900-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-24 | — | — | US | disclosed |
| EP-2705037-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-03-12 | — | — | EP | disclosed |
| EP-2705038-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER IP GMBH (DE) | 2013-11-14 | — | — | US | disclosed |
| WO-2013131923-A1 | SUBSTITUTED AZABICYCLES AND USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-12 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012152629-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-11-15 | — | — | WO | disclosed |
| WO-2012152630-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-11-15 | — | — | WO | disclosed |
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029002-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | PKM, BRD3, TNNI3 | PDE10A 2782/4885ALDH1A1 1760/4885KDM4E 3894/4885 |
| US-20130303559-A1 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES | PKM, BRD3, TNNI3 | PDE10A 2782/4885ALDH1A1 1760/4885KDM4E 3894/4885 |
| US-20140113900-A1 | SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF | TPMT, TNNI3, PPIP5K2 | PDE10A 2758/4885ALDH1A1 818/4885KDM4E 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.