Sugi Predict

Sugi Predict / Compounds / SCHEMBL13739489

SCHEMBL13739489

SCHEMBL13739489

CCN(CCCCN)S(C)(=O)=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CHRM2 P08172 1/20 0.39
▸ MPO P05164 1/20 0.35
▸ SLC6A4 P31645 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ APP P05067 1/20 0.34
▸ DNM1 Q05193 4/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA14 Q9ULX7 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ EPHX1 P07099 1/20 0.33
▸ BLM P54132 1/20 0.32
▸ PMP22 Q01453 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23775289 0.84 CA1 (0.37) MPOSLC6A4LMNASMN1; SMN2CA12
SCHEMBL15746839 0.82 DNM1 (0.39) MPOSLC6A4DNM1CA12CA1
SCHEMBL17676553 0.80 DNM1 (0.42) DNM1CA12CA1CA2
SCHEMBL17676601 0.80 DNM1 (0.42) DNM1CA12CA1CA2
SCHEMBL13064494 0.79 CA1 (0.40) MPOSLC6A4KDM4ECA12CA1
SCHEMBL13831924 0.78 MPO (0.35) MPOSLC6A4CA1
SCHEMBL18656046 0.76 MPO (0.36) MPOSLC6A4CA12CA1CA2
SCHEMBL15745496 0.75 KDM4C (0.35) MPOSLC6A4LMNATSHRBLM
SCHEMBL8241145 0.75 SMN1; SMN2 (0.35) MPOSLC6A4LMNASMN1; SMN2CA12
SCHEMBL13693145 0.74 CA1 (0.57) MPOSLC6A4KDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10544100-B2 Autophagy inhibitors TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2020-01-28 — — US disclosed
US-20180290980-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2018-10-11 — — US disclosed
US-20170000784-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2017-01-05 — — US disclosed
US-20160137607-A1 Autophagy Inhibitors VAN ANDEL RESEARCH INSTITUTE 2016-05-19 — — US disclosed
US-9221760-B2 Autophagy inhibitors VAN ANDEL RESEARCH INSTITUTE (US) 2015-12-29 — — US disclosed
WO-2015085229-A1 AUTOPHAGY INHIBITORS VAN ANDEL RESEARCH INSTITUTE (US) 2015-06-11 — — WO disclosed
US-20140148451-A1 Autophagy Inhibitors TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2014-05-29 — — US disclosed
WO-2012154879-A2 AUTOPHAGY INHIBITORS VAN ANDEL RESEARCH INSTITUTE (US) 2012-11-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544100-B2 Autophagy inhibitors BECN1, ATG7, SQSTM1 CHRM2 4778/4885MPO 2879/4885SLC6A4 2839/4885
US-20170000784-A1 Autophagy Inhibitors BRAF, HRAS, NRAS CHRM2 4797/4885MPO 4385/4885SLC6A4 3724/4885
US-20140148451-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 CHRM2 4778/4885MPO 2879/4885SLC6A4 2839/4885
US-20160137607-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 CHRM2 4778/4885MPO 2879/4885SLC6A4 2839/4885
US-20180290980-A1 Autophagy Inhibitors BECN1, ATG7, SQSTM1 CHRM2 4778/4885MPO 2879/4885SLC6A4 2839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.