Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391966 | 0.80 | KMT2A (0.71) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| Guanfacine SCHEMBL35095 | 0.79 | ADRA2A (1.00) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| Guanfacine SCHEMBL15603414 | 0.77 | ADRA2A (1.00) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL3561938 | 0.77 | KMT2A (0.57) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| Guanfacine SCHEMBL1133622 | 0.76 | ADRA2A (0.93) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL109215 | 0.76 | AKR1B1 (1.00) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL11243678 | 0.76 | AKR1B1 (0.68) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL2525484 | 0.76 | AKR1B1 (0.68) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL8485672 | 0.75 | AKR1B1 (0.55) | KMT2AADRA2AMEN1LMNACYP3A4 | |
| SCHEMBL11389434 | 0.74 | KMT2A (0.63) | KMT2AADRA2AMEN1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088141-A2 | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same | Kirin Pharma Kabushiki Kaisha (JP) | 2009-08-12 | — | — | EP | disclosed |