Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 12/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL13739996 | 0.99 | RIPK1 (0.56) | RIPK1TAS1R3TAS1R1PLK1TRPM8 | |
| SCHEMBL2299005 | 0.83 | PLK1 (0.77) | RIPK1PLK1TRPM8EGLN1ALOX15 | |
| SCHEMBL3362629 | 0.81 | HDAC6 (0.65) | PLK1TRPM8EGLN1HTTMEN1 | |
| SCHEMBL21642302 | 0.81 | NPC1 (0.69) | HTTMEN1KMT2A | |
| SCHEMBL7954464 | 0.81 | EGLN1 (0.48) | TAS1R3TAS1R1PLK1TRPM8EGLN1 | |
| SCHEMBL24809084 | 0.80 | ALDH1A1 (0.50) | PLK1TRPM8EGLN1ALOX15HTT | |
| SCHEMBL2671065 | 0.80 | ALOX15 (0.77) | PLK1EGLN1ALOX15HTTMEN1 | |
| SCHEMBL29893321 | 0.80 | ALOX15 (0.77) | PLK1EGLN1ALOX15HTTMEN1 | |
| SCHEMBL4066938 | 0.79 | ALDH1A1 (0.58) | RIPK1TRPM8ALOX15HTTHPGDS | |
| SCHEMBL9360254 | 0.78 | MEN1 (0.55) | PLK1EGLN1ALOX15HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678329-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012154274-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-11-15 | — | — | WO | disclosed |