Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745274 | 0.82 | MET (0.52) | METMAOBMEN1KMT2AADORA2A | |
| SCHEMBL24359756 | 0.81 | RAB9A (0.49) | IDO1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL29817949 | 0.78 | KDM4E (0.53) | MAOBIDO1MEN1KMT2AMAPT | |
| SCHEMBL2615353 | 0.78 | MAOB (0.46) | MAOBIDO1MAPTNPC1RAB9A | |
| SCHEMBL29431721 | 0.78 | HSD17B1 (0.53) | MAP4K4ACHE | |
| SCHEMBL14018487 | 0.78 | KDM4E (0.53) | MAOBIDO1MEN1KMT2AMAPT | |
| SCHEMBL11630165 | 0.78 | MAOB (0.46) | MAOBIDO1MEN1KMT2AMAPT | |
| SCHEMBL2615360 | 0.77 | KDM4E (0.56) | MAOBIDO1KDM4ENPC1RAB9A | |
| SCHEMBL13729206 | 0.77 | MAOB (0.47) | MAOBIDO1MEN1KMT2AMAPT | |
| SCHEMBL10165319 | 0.76 | RAB9A (0.52) | METMAOBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |