Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746724 | 0.78 | KDM4E (0.37) | HTR6KDM4ELMNASIGMAR1HTR1A | |
| SCHEMBL13746725 | 0.78 | KDM4E (0.40) | HTR6KDM4ETDP1LMNASIGMAR1 | |
| SCHEMBL13747092 | 0.71 | SIGMAR1 (0.50) | HTR6KDM4ETDP1SIGMAR1HTR1A | |
| SCHEMBL4204074 | 0.71 | ALDH1A1 (0.45) | KDM4ETDP1ALDH1A1KMT2A | |
| SCHEMBL4030106 | 0.70 | SCARB1 (0.61) | KDM4EALDH1A1KMT2A | |
| SCHEMBL13747174 | 0.69 | SCARB1 (0.63) | HTR6KDM4ETDP1HTR1AADRA2A | |
| SCHEMBL13747535 | 0.69 | SCARB1 (0.63) | HTR6KDM4ETDP1HTR1AADRA2A | |
| SCHEMBL11161450 | 0.61 | SIGMAR1 (0.51) | SMN1; SMN2KDM4ELMNASIGMAR1CYP2D6 | |
| SCHEMBL2088517 | 0.61 | KDM4E (0.50) | SMN1; SMN2KDM4ETDP1LMNACYP2D6 | |
| SCHEMBL14399503 | 0.61 | KDM4E (0.63) | SMN1; SMN2KDM4ETDP1LMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |