Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 10/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587818 | 0.93 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL7121279 | 0.92 | POLB (0.51) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL29800655 | 0.92 | POLB (0.51) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL12960291 | 0.86 | AR (0.42) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL1854865 | 0.84 | ALDH1A1 (0.51) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL12890393 | 0.84 | ESR1 (0.47) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL12960258 | 0.84 | TLR8 (0.53) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| SCHEMBL9745713 | 0.84 | KDM4E (0.49) | SMN1; SMN2KDM4EPOLBGAAAR | |
| SCHEMBL8975487 | 0.83 | POLB (0.73) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL8464515 | 0.82 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EPOLBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452959-B2 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-18 | — | — | US | claimed |
| EP-1507816-A4 | OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF | US GOV SEC NAVY (US) | 2006-05-31 | — | — | EP | claimed |
| EP-1507816-A1 | OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (US) | 2005-02-23 | — | — | EP | claimed |
| US-20040181029-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY, THE | 2004-09-16 | — | — | US | claimed |
| US-20040181027-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE | 2004-09-16 | — | — | US | claimed |
| US-20040181028-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, THE, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE | 2004-09-16 | — | — | US | claimed |
| US-20030229198-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF, THE | 2003-12-11 | — | — | US | claimed |
| WO-2003091312-A1 | OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRSENTED BY THE SECRETARY OF THE NAVY (US) | 2003-11-06 | — | — | WO | claimed |
| US-8530607-B2 | Aromatic ether and alkynyl containing phthalonitriles | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110288254-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110263775-A1 | PHOSPHINE OXIDE CONTAINING PHTHALONITRILES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-10-27 | — | — | US | disclosed |
| US-8039576-B2 | Aromatic ether and alkynyl containing phthalonitriles | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2011-10-18 | — | — | US | disclosed |
| US-7511113-B2 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-03-31 | — | — | US | disclosed |
| US-20090069484-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2009-03-12 | — | — | US | disclosed |
| US-20040181029-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY, THE | 2004-09-16 | — | — | US | disclosed |
| US-20040181027-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE | 2004-09-16 | — | — | US | disclosed |
| US-20040181028-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, THE, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE | 2004-09-16 | — | — | US | disclosed |
| US-6756470-B2 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY | 2004-06-29 | — | — | US | disclosed |
| US-20030229198-A1 | Oligomeric hydroxy arylether phthalonitiles and synthesis thereof | NAVY, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF, THE | 2003-12-11 | — | — | US | disclosed |
| WO-2003091312-A1 | OLIGOMERIC HYDROXY ARYLETHER PHTHALONITILES AND SYNTHESIS THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRSENTED BY THE SECRETARY OF THE NAVY (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288254-A1 | AROMATIC ETHER AND ALKYNYL CONTAINING PHTHALONITRILES | PNN, BECN1, ACIN1 | SMN1; SMN2 1799/4885KDM4E 675/4885POLB 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.