Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12134373 | 0.86 | ALDH1A1 (0.66) | TDP1L3MBTL1ALDH1A1ACHECYP1A2 | |
| SCHEMBL2866490 | 0.85 | ALDH1A1 (0.55) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL12134368 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL877279 | 0.84 | KMT2A (0.73) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL29459522 | 0.84 | KMT2A (0.73) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL9878928 | 0.82 | KMT2A (0.71) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL11754615 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2TDP1MAPTALDH1A1ACHE | |
| SCHEMBL27731394 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL6790333 | 0.80 | TDP1 (0.71) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL4351612 | 0.80 | TDP1 (0.66) | SMN1; SMN2TDP1L3MBTL1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102537-A1 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2009-08-20 | — | — | WO | disclosed |