SCHEMBL2866490

SCHEMBL2866490

C=C(CCCN1C(=O)c2ccccc2C1=O)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.55
ACHE P22303 1/20 0.55
KMT2A Q03164 4/20 0.54
HDAC8 Q9BY41 3/20 0.54
HDAC3 O15379 2/20 0.54
HDAC4 P56524 2/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC7 Q8WUI4 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC10 Q969S8 2/20 0.54
HDAC11 Q96DB2 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
HDAC9 Q9UKV0 2/20 0.54
HDAC5 Q9UQL6 2/20 0.54
MEN1 O00255 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
HPGD P15428 2/20 0.54
LMNA P02545 2/20 0.52
TDP1 Q9NUW8 2/20 0.51
MAPT P10636 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10932459 0.95 HDAC8 (0.60) ALDH1A1KMT2AHDAC8HDAC3HDAC4
SCHEMBL2395293 0.90 POLB (0.55) ALDH1A1KMT2AHDAC8HDAC3HDAC4
SCHEMBL13747673 0.85 SMN1; SMN2 (0.56) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL27731394 0.83 ALDH1A1 (0.57) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL877279 0.83 KMT2A (0.73) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL29459522 0.83 KMT2A (0.73) ALDH1A1ACHEKMT2AHDAC8HDAC3
Hydrochloric Acid SCHEMBL9878928 0.81 KMT2A (0.71) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL12134373 0.81 ALDH1A1 (0.66) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL11754615 0.81 ALDH1A1 (0.62) ALDH1A1ACHEKMT2AHDAC8HDAC3
SCHEMBL12134368 0.81 SMN1; SMN2 (0.51) ALDH1A1ACHEKMT2AHDAC8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9242498-B2 Printing method, printing device, printed material and molded article SEIKO EPSON CORPORATION (JP) 2016-01-26 US disclosed
US-20150353751-A1 INKJET INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, AND PROCESS FOR PRODUCING MOLDED PRINTED MATERIAL FUJIFILM CORPORATION (JP) 2015-12-10 US disclosed
US-8927094-B2 Printed article and method of manufacturing printed article SEIKO EPSON CORPORATION (JP) 2015-01-06 US disclosed
US-7713462-B2 Ink composition, inkjet recording method, printed material, and process for producing molded printed material FUJIFILM CORPORATION (JP) 2010-05-11 US disclosed
US-20090244116-A1 INKJET RECORDING METHOD AND INKJET RECORDING SYSTEM FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
US-20090214797-A1 INKJET INK COMPOSITION, AND INKJET RECORDING METHOD AND PRINTED MATERIAL EMPLOYING SAME FUJIFILM CORPORATION (JP) 2009-08-27 US disclosed
US-20090087626-A1 INK COMPOSITION, INKJET RECORDING METHOD, PRINTED MATERIAL, AND PROCESS FOR PRODUCING MOLDED PRINTED MATERIAL FUJIFILM CORPORATION (JP) 2009-04-02 US disclosed
EP-0968182-B1 HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY DARWIN DISCOVERY LTD (GB) 2004-05-06 EP disclosed
US-20030207889-A1 Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity OWEN DAVID ALAN (GB) 2003-11-06 US disclosed
US-6118001-A ANTICANCER AGENT; ANTIARTHRITIC AGENT DARWIN DISCOVERY, LTD. (GB) 2000-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030207889-A1 Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity MMP13, MMP2, MMP9 ALDH1A1 408/4885ACHE 1513/4885KMT2A 1581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.