Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809015 | 0.94 | KIF11 (0.45) | KIF11HHATHTTMAPTNPSR1 | |
| SCHEMBL13809014 | 0.85 | KIF11 (0.48) | KIF11HHATMAPTNPSR1L3MBTL1 | |
| SCHEMBL13809017 | 0.82 | KIF11 (0.50) | KIF11HHATMEN1KMT2AMAPT | |
| SCHEMBL13809005 | 0.77 | KIF11 (0.50) | KIF11KMT2AHTTTSHRGRIN2C | |
| SCHEMBL13809025 | 0.76 | KIF11 (0.42) | KIF11MEN1KMT2AGRIN2CSMN1; SMN2 | |
| SCHEMBL13748440 | 0.73 | MAPT (0.66) | MAPTNPSR1L3MBTL1POLBPKM | |
| SCHEMBL11713375 | 0.69 | TRPV1 (0.51) | KIF11MEN1KMT2AHTTMAPT | |
| SCHEMBL13809243 | 0.69 | KIF11 (0.53) | KIF11MEN1KMT2AGRIN2CALDH1A1 | |
| SCHEMBL10025906 | 0.64 | OPRD1 (0.39) | HTTNPSR1TSHRGRIN2CPOLB | |
| SCHEMBL11718509 | 0.63 | KIF11 (0.59) | KIF11HTTMAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009102377-A2 | ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES | MAXTHERA INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009073545-A2 | TETRAHYDRO-ISOQUINOLINE PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | MAXTHERA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |