Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809005 | 0.90 | KIF11 (0.50) | KIF11GRIN2CKMT2AKDM4EALDH1A1 | |
| SCHEMBL13809017 | 0.81 | KIF11 (0.50) | KIF11GRIN2CKMT2AMEN1KDM4E | |
| SCHEMBL13809025 | 0.79 | KIF11 (0.42) | KIF11GRIN2CKMT2AMEN1KDM4E | |
| SCHEMBL13809242 | 0.78 | KIF11 (0.45) | KIF11GRIN2CKMT2AKDM4EALDH1A1 | |
| SCHEMBL13748721 | 0.76 | MEN1 (0.44) | KIF11KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL13809241 | 0.75 | GRIN2C (0.41) | GRIN2CKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL10025892 | 0.75 | P2RX7 (0.39) | GRIN2CHCRTR1HCRTR2P2RX7 | |
| SCHEMBL13809015 | 0.74 | KIF11 (0.45) | KIF11GRIN2CKDM4EALDH1A1HPGD | |
| SCHEMBL13809014 | 0.71 | KIF11 (0.48) | KIF11GRIN2CKDM4EALDH1A1HPGD | |
| SCHEMBL11718509 | 0.69 | KIF11 (0.59) | KIF11GRIN2CKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073545-A2 | TETRAHYDRO-ISOQUINOLINE PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | MAXTHERA, INC. (US) | 2009-06-11 | — | — | WO | disclosed |