SCHEMBL1374872

SCHEMBL1374872

COC1C(O)[C@H](n2cnc3c(=O)[nH]c(N)nc32)O[C@@H]1CO

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HINT1 P49773 5/20 0.61
HPGD P15428 2/20 0.61
NT5E P21589 1/20 0.59
GSK3A P49840 2/20 0.56
RPS6KA3 P51812 2/20 0.56
MAPK14 Q16539 2/20 0.56
TGM2 P21980 1/20 0.55
IMPDH2 P12268 1/20 0.54
IMPDH1 P20839 1/20 0.54
PNP P00491 1/20 0.53
ADORA2A P29274 1/20 0.53
ADORA2B P29275 1/20 0.53
STING1 Q86WV6 1/20 0.53
TAS1R3 Q7RTX0 1/20 0.52
TAS1R1 Q7RTX1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22883381 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL20444711 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL1639395 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL23425431 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL16359926 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL23679991 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL17972356 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL17976623 1.00 HINT1 (0.61) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL28911220 0.92 HINT1 (0.60) HINT1HPGDNT5EGSK3ARPS6KA3
SCHEMBL26515 0.92 HPGD (0.61) HINT1HPGDNT5EGSK3ARPS6KA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025229572-A1 EPSTEIN-BARR VIRUS ANTIGEN-ENCODING MESSENGER RIBONUCLEIC ACID AND ANTIGEN PROTEIN VACCINES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2025-11-06 WO claimed
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
CN-117925755-A Synthesis method of nucleoside intermediate 2' -O-methyl guanosine 康羽生命科学技术(苏州)有限公司 2024-04-26 CN claimed
EP-4271389-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA Rejuvenation Technologies Inc. (US) 2023-11-08 EP claimed
CN-116916936-A Compositions and methods for delivering RNA 再生技术有限责任公司 2023-10-20 CN claimed
CN-116144771-A Molecular parting gene group of hepatocellular carcinoma, diagnostic product and application 南京鼓楼医院 2023-05-23 CN claimed
WO-2022147039-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES INC. (US) 2022-07-07 WO claimed
EP-2010659-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA Epicentre Technologies (US) 2009-01-07 EP claimed
WO-2007120863-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES (US) 2007-10-25 WO claimed
EP-4717779-A2 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TriLink BioTechnologies, LLC (US) 2026-04-01 EP disclosed
EP-4276189-B1 INITIATING CAPPED OLIGONUCLEOTIDE PRIMERS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2026-04-01 EP disclosed
EP-4424835-B1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2026-01-21 EP disclosed
WO-2025229572-A1 EPSTEIN-BARR VIRUS ANTIGEN-ENCODING MESSENGER RIBONUCLEIC ACID AND ANTIGEN PROTEIN VACCINES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2025-11-06 WO disclosed
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US disclosed
EP-1223173-A2 Novel 2'-O-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof ISIS PHARMACEUTICALS, INC. (US) 2002-07-17 EP disclosed
US-6110901-A 3'-DEOXYRIBOCYTOSINE, 3'-DEOXYRIBOURACIL, AND/OR 3'-DEOXYRIBOGUANINE AMERICAN CYANAMID COMPANY (US) 2000-08-29 US disclosed
US-5914396-A 2'-O-modified nucleosides and phosphoramidites ISIS PHARMACEUTICALS, INC. (US) 1999-06-22 US disclosed
US-5506351-A Process for the preparation of 2'-O-alkyl guanosine and related compounds ISIS PHARMACEUTICALS (US) 1996-04-09 US disclosed
US-5213972-A Production of thymidine and deoxyuridine, intermediates for AZT CHEMGEN CORPORATION (US) 1993-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA RNASE1, POLRMT, TERT HINT1 4350/4885HPGD 3841/4885NT5E 2462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.