SCHEMBL1375338

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL31545399	0.84	ESR1 (0.47)	ESR1SMPD1NR5A1AKR1C4AKR1C3
	SCHEMBL11871738	0.83	SMPD1 (0.55)	ESR1ALOX5SMPD1NR5A1AKR1C4
	Hx-1171 SCHEMBL29375871	0.81	ESR1 (0.50)	ESR1ALOX5NR5A1
	Hx-1171 SCHEMBL688955	0.81	ESR1 (0.50)	ESR1ALOX5NR5A1
	SCHEMBL7607111	0.81	THRA (0.48)	ESR1ALOX5NR5A1AKR1C4AKR1C3
	SCHEMBL31546083	0.80	NPC1 (0.54)	ESR1CYP3A4
	SCHEMBL31545314	0.80	PTGS2 (0.50)	ALOX5CYP3A4
	SCHEMBL9511132	0.77	ESR1 (0.42)	ESR1ALOX5SMPD1NR5A1LMNA
	SCHEMBL31544988	0.77	PTGS2 (0.50)	ALOX5CYP3A4
	SCHEMBL5523292	0.76	ALOX5 (0.46)	ESR1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.