Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901678 | 0.87 | CCR2 (0.44) | POLBLMNASMN1; SMN2USP2TSHR | |
| SCHEMBL4472975 | 0.86 | CCR2 (0.52) | POLB | |
| SCHEMBL4161857 | 0.86 | POLB (0.69) | POLBLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL13758488 | 0.84 | POLB (0.55) | POLBLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL13613090 | 0.84 | POLB (0.55) | POLBLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL18901429 | 0.83 | SYK (0.49) | MAPT | |
| SCHEMBL10993938 | 0.81 | POLB (0.90) | POLBLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL2187327 | 0.81 | POLB (0.71) | POLBLMNAHTTSMN1; SMN2USP2 | |
| SCHEMBL22499987 | 0.81 | NOTUM (0.57) | POLBLMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL29689683 | 0.81 | NOTUM (0.57) | POLBLMNAHTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |