Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590259 | 0.84 | ABL1 (0.38) | TRPV1ABL1SRCKDR | |
| SCHEMBL13763280 | 0.78 | TRPV1 (0.55) | TRPV1TP53THRBSMN1; SMN2NR1H4 | |
| SCHEMBL13544497 | 0.77 | KIT (0.56) | TRPV1TP53THRBSMN1; SMN2ABL1 | |
| SCHEMBL13544321 | 0.77 | ABL1 (0.38) | TRPV1ABL1SRCKDR | |
| SCHEMBL13544369 | 0.76 | TRPV1 (0.78) | TRPV1SMN1; SMN2KDRMEN1KMT2A | |
| SCHEMBL13544518 | 0.73 | NR1H4 (0.49) | TRPV1TP53THRBSMN1; SMN2NR1H4 | |
| SCHEMBL13763274 | 0.72 | TRPV1 (0.80) | TRPV1 | |
| SCHEMBL13544523 | 0.70 | RAB9A (0.52) | TRPV1TP53THRBSMN1; SMN2NR1H4 | |
| SCHEMBL13544749 | 0.68 | HSD11B1 (0.54) | TRPV1TP53THRBSMN1; SMN2NR1H4 | |
| SCHEMBL13544362 | 0.68 | TRPV1 (0.80) | TRPV1TP53THRBSMN1; SMN2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576099-B2 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | RENOVIS, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20080300243-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300243-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | TRPV1 1/4885TP53 4006/4885THRB 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.