Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3976700 | 1.00 | CTSK (0.39) | CTSKUTS2RCTSSKMT2ACCR5 | |
| SCHEMBL3976705 | 1.00 | CTSK (0.39) | CTSKUTS2RCTSSKMT2ACCR5 | |
| SCHEMBL3976118 | 0.91 | UTS2R (0.38) | CTSKUTS2RCTSSKMT2ACCR5 | |
| SCHEMBL3978130 | 0.91 | UTS2R (0.38) | CTSKUTS2RCTSSKMT2ACCR5 | |
| SCHEMBL10306122 | 0.80 | KMT2A (0.41) | CTSKUTS2RCTSSKMT2ACCR5 | |
| SCHEMBL12188091 | 0.78 | CYP2D6 (0.42) | CCR5ALDH1A1 | |
| SCHEMBL6008976 | 0.78 | KMT2A (0.39) | CTSKUTS2RCTSSKMT2A | |
| SCHEMBL31401115 | 0.78 | KMT2A (0.39) | CTSKUTS2RCTSSKMT2A | |
| SCHEMBL5067807 | 0.77 | DRD2 (0.45) | CTSKCTSSKMT2AL3MBTL1 | |
| SCHEMBL3975026 | 0.76 | CTSK (0.37) | CTSKUTS2RCTSSKMT2ACCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563805-B2 | 7-[3-Amino-3,4-dimethylpyrrolidine-1-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid: quinoline bactericide; broad spectrum, strong antibacterial activity for Grampositive/-negative including multiple resistant cocci; side effect reductcion; drug design | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |