Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977058 | 0.80 | RORC (0.43) | CTSKKMT2ANPSR1GRIN2B | |
| SCHEMBL10306097 | 0.80 | RORC (0.43) | CTSKKMT2ANPSR1GRIN2B | |
| SCHEMBL3975384 | 0.80 | RORC (0.43) | CTSKKMT2ANPSR1GRIN2B | |
| SCHEMBL3975383 | 0.80 | RORC (0.43) | CTSKKMT2ANPSR1GRIN2B | |
| SCHEMBL8541686 | 0.79 | SIGMAR1 (0.44) | DRD2SIGMAR1NAMPTCTSKCTSS | |
| SCHEMBL6008955 | 0.79 | SIGMAR1 (0.44) | DRD2SIGMAR1NAMPTCTSKCTSS | |
| SCHEMBL13764767 | 0.77 | CTSK (0.39) | CTSKCTSSKMT2AL3MBTL1 | |
| SCHEMBL3976700 | 0.77 | CTSK (0.39) | CTSKCTSSKMT2AL3MBTL1 | |
| SCHEMBL3976705 | 0.77 | CTSK (0.39) | CTSKCTSSKMT2AL3MBTL1 | |
| SCHEMBL4775252 | 0.75 | SIGMAR1 (0.47) | DRD2SIGMAR1NAMPTCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1882689-B1 | TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2013-07-10 | — | — | EP | disclosed |
| EP-1882689-A1 | TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2008-01-30 | — | — | EP | disclosed |