SCHEMBL1376852

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1379227	0.89	MLKL (0.41)	HTR2AHTR2CKDM4EALDH1A1GLA
	SCHEMBL4499201	0.79	MEN1 (0.38)	ALDH1A1CNR1MEN1KMT2ALMNA
	SCHEMBL1379087	0.78	DAO (0.41)	KDM4EALDH1A1MEN1KMT2AHPGD
	SCHEMBL4499087	0.73	CYP19A1 (0.42)	KDM4EALDH1A1HTTTP53HSD17B10
	SCHEMBL4490551	0.72	MTNR1A (0.38)	KDM4EALDH1A1GAAMEN1KMT2A
	SCHEMBL4510000	0.71	MTNR1A (0.52)	KDM4EMEN1KMT2AHPGDHSD17B10
	SCHEMBL1378002	0.71	MLKL (0.39)	HTR2AHTR2CKDM4EALDH1A1GLA
	SCHEMBL4498277	0.69	MTNR1A (0.61)	KDM4EALDH1A1MEN1KMT2AHPGD
	SCHEMBL4498964	0.69	MTNR1A (0.42)	KDM4EALDH1A1MEN1KMT2AHPGD
	SCHEMBL8230415	0.69	CYP19A1 (0.57)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.