Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRE | P78334 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291376 | 0.86 | GABRP (0.46) | CDK4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14084729 | 0.76 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3318612 | 0.76 | IDH1 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20038223 | 0.74 | VNN1 (0.39) | CDK4PANK3SMN1; SMN2HSD11B1 | |
| SCHEMBL2234473 | 0.73 | MAPT (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20038221 | 0.71 | HSD11B1 (0.37) | CDK4PANK3SMN1; SMN2HSD11B1CRBN | |
| SCHEMBL20249346 | 0.71 | PANK3 (0.37) | CDK4PANK3SMN1; SMN2HSD11B1 | |
| SCHEMBL18291302 | 0.71 | PANK3 (0.51) | CDK4PANK3HSD11B1 | |
| SCHEMBL13769030 | 0.71 | GABRP (0.48) | CDK4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20037975 | 0.69 | SMN1; SMN2 (0.44) | CDK4PANK3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085185-A1 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |