Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30254688 | 0.88 | LMNA (0.47) | TNFALDH1A1MAPTXDHKMT2A | |
| SCHEMBL13769678 | 0.85 | MITF (0.41) | MITFALDH1A1MAPTRAB9AHSD17B10 | |
| SCHEMBL12480375 | 0.84 | KDM4E (0.37) | ALDH1A1JAK2JAK1JAK3KDM4E | |
| SCHEMBL13769669 | 0.77 | MKNK2 (0.42) | ALDH1A1MAPTRAB9AHSD17B10KMT2A | |
| SCHEMBL31208191 | 0.77 | ALDH1A1 (0.49) | MITFTNFALDH1A1MAPTRAB9A | |
| SCHEMBL13769524 | 0.76 | MITF (0.41) | MITFTNFALDH1A1MAPTHSD17B10 | |
| SCHEMBL13769757 | 0.76 | MITF (0.41) | MITFALDH1A1MAPTRAB9AHSD17B10 | |
| SCHEMBL13769935 | 0.75 | HSD17B10 (0.44) | MITFTNFALDH1A1MAPTRAB9A | |
| SCHEMBL28313408 | 0.75 | FDPS (0.49) | MITFTNFALDH1A1MAPTRAB9A | |
| SCHEMBL13769541 | 0.72 | MEN1 (0.39) | ALDH1A1MAPTHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |