SCHEMBL137701

SCHEMBL137701

Cc1ccc(S(=O)(=O)Oc2ccc3nc(C#N)ccc3c2)c([N+](=O)[O-])c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.46
ALPL P05186 3/20 0.43
RELA Q04206 4/20 0.39
NFKBIA P25963 2/20 0.39
MEN1 O00255 5/20 0.37
KMT2A Q03164 5/20 0.37
AGTR1 P30556 1/20 0.37
OPRK1 P41145 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
CTSB P07858 2/20 0.37
ALPI P09923 2/20 0.37
MCOLN3 Q8TDD5 2/20 0.36
HPGD P15428 2/20 0.36
MAPT P10636 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140679 0.92 NQO1 (0.46) NQO1ALPLRELANFKBIAMEN1
SCHEMBL140436 0.81 PTPN1 (0.43) ALPLRELANFKBIAMEN1KMT2A
SCHEMBL140110 0.73 GPR35 (0.34) ALPLRELANFKBIAMEN1KMT2A
SCHEMBL138994 0.73 PTPN1 (0.43) ALPLMEN1KMT2AALPIMAPT
SCHEMBL8002770 0.71 NQO1 (0.64) NQO1MEN1KMT2ATDP1HPGD
SCHEMBL29577728 0.70 ALPL (0.49) ALPLMEN1KMT2ATDP1ALPI
SCHEMBL17856924 0.68 PTPN1 (0.38) RELANFKBIAMEN1KMT2AMCOLN3
SCHEMBL2964677 0.67 TTR (0.56) NQO1TDP1CTSBMAPTSMN1; SMN2
SCHEMBL139851 0.67 ALPL (0.49) ALPLMEN1KMT2AALPIHPGD
SCHEMBL28033544 0.66 TSHR (0.51) RELANFKBIAMEN1KMT2AAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889849-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2021-01-12 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-A1 OXIDIZED GLUTATHIONE ASSAY Promega Corporation (US) 2013-07-10 EP disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed