SCHEMBL140679

SCHEMBL140679

Cc1ccc([N+](=O)[O-])c(S(=O)(=O)Oc2ccc3nc(C#N)ccc3c2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.46
ALPL P05186 3/20 0.43
MEN1 O00255 5/20 0.37
KMT2A Q03164 5/20 0.37
CTSB P07858 2/20 0.37
ALPI P09923 2/20 0.37
MAPT P10636 5/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
RELA Q04206 2/20 0.36
MITF O75030 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL137701 0.92 NQO1 (0.46) NQO1ALPLMEN1KMT2ACTSB
SCHEMBL138994 0.81 PTPN1 (0.43) ALPLMEN1KMT2AALPIMAPT
SCHEMBL140112 0.73 GPR35 (0.34) ALPLMEN1KMT2AALPIMAPT
SCHEMBL140436 0.73 PTPN1 (0.43) ALPLMEN1KMT2AMAPTKDM4E
SCHEMBL8002770 0.71 NQO1 (0.64) NQO1MEN1KMT2AMAPTHPGD
SCHEMBL27343052 0.69 CYP3A4 (0.46) ALPLMEN1KMT2AALPIMAPT
SCHEMBL2964677 0.67 TTR (0.56) NQO1CTSBMAPTSMN1; SMN2ALDH1A1
SCHEMBL139851 0.67 ALPL (0.49) ALPLMEN1KMT2AALPIMAPT
SCHEMBL6295751 0.66 MERTK (0.52) MEN1KMT2AMAPTHPGDSMN1; SMN2
SCHEMBL3380304 0.66 MEN1 (0.60) MEN1KMT2AMAPTHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889849-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2021-01-12 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-A1 OXIDIZED GLUTATHIONE ASSAY Promega Corporation (US) 2013-07-10 EP disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed