Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.71 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28547256 | 0.85 | HSD11B1 (0.72) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL12577229 | 0.84 | HSD11B1 (1.00) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL16660516 | 0.84 | HSD11B1 (0.73) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL28395917 | 0.83 | HSD11B1 (0.81) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL28547258 | 0.78 | HSD11B1 (0.88) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL28392708 | 0.78 | RECQL (0.73) | HSD11B1RECQLNPC1ALDH1A1RAB9A | |
| SCHEMBL13774627 | 0.77 | PTPN1 (0.63) | RECQLALDH1A1PTPN1MEN1KMT2A | |
| SCHEMBL23877960 | 0.77 | HSD11B1 (0.43) | HSD11B1RAB9AACLYPTPN1KMT2A | |
| SCHEMBL29784281 | 0.76 | RXRA (0.72) | NPC1ALDH1A1RAB9APTPN1MEN1 | |
| SCHEMBL2344585 | 0.76 | RXRA (0.72) | NPC1ALDH1A1RAB9APTPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090179638-A1 | ASSAY FOR IDENTIFYING INHIBITORS OF NEURONAL APOPTOTIC PATHWAYS | AEGERA THERAPEUTICS INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| US-20090179638-A1 | ASSAY FOR IDENTIFYING INHIBITORS OF NEURONAL APOPTOTIC PATHWAYS | AEGERA THERAPEUTICS INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| WO-2007087716-A1 | ASSAY FOR IDENTIFYING INHIBITORS OF NEURONAL APOPTOTIC PATHWAYS | AEGERA THERAPEUTICS INC. (CA) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090179638-A1 | ASSAY FOR IDENTIFYING INHIBITORS OF NEURONAL APOPTOTIC PATHWAYS | HSPBP1, HSP90AB1, HSP90AB2P | HSD11B1 3069/4885RECQL 2782/4885NPC1 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.