Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.49 |
| ▸ | TPSD1 | Q9BZJ3 | 4/20 | 0.49 |
| ▸ | TPSG1 | Q9NRR2 | 4/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1231646 | 0.92 | HTT (0.62) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL2390661 | 0.88 | HTT (0.56) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL6420313 | 0.85 | GAA (0.58) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL20785502 | 0.83 | ALDH1A1 (0.47) | HTTTPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL22146953 | 0.81 | HTT (0.48) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL13418028 | 0.80 | CASP1 (0.43) | — | |
| SCHEMBL25333732 | 0.80 | LMNA (0.63) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL1412214 | 0.78 | TPSAB1 (0.50) | HTTTPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL11527408 | 0.78 | HTT (0.54) | HTTTPSAB1TPSD1TPSG1TGM2 | |
| SCHEMBL16620495 | 0.78 | ALDH1A1 (0.47) | TPSAB1TPSD1TPSG1ELANEPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083005-A1 | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2009-07-29 | — | — | EP | disclosed |