SCHEMBL1378747

SCHEMBL1378747

O=Cc1ncc2c(n1)NC(=O)CO2

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 9/20 0.41
MMP12 P39900 1/20 0.33
NR3C1 P04150 1/20 0.33
CYP11B1 P15538 2/20 0.33
CYP11B2 P19099 2/20 0.33
ALDH1A1 P00352 2/20 0.32
MAPT P10636 2/20 0.32
HPGD P15428 1/20 0.32
PARP1 P09874 1/20 0.31
KCNH2 Q12809 1/20 0.31
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12046275 0.79 NR3C2 (0.45) NR3C2NR3C1CYP11B1CYP11B2ALDH1A1
SCHEMBL15970384 0.79 NR3C2 (0.45) NR3C2NR3C1CYP11B1CYP11B2ALDH1A1
SCHEMBL1333452 0.78 NR3C2 (0.42) NR3C2MMP12NR3C1CYP11B1CYP11B2
SCHEMBL19629973 0.78 NR3C2 (0.42) NR3C2MMP12NR3C1CYP11B1CYP11B2
SCHEMBL19250690 0.76 NR3C2 (0.38) NR3C2NR3C1PKM
SCHEMBL20754037 0.75 NR3C2 (0.43) NR3C2MMP12NR3C1ALDH1A1MAPT
SCHEMBL22210583 0.74 NR3C2 (0.42) NR3C2MMP12NR3C1CYP11B1CYP11B2
SCHEMBL17095009 0.72 PARP1 (0.37) NR3C2MMP12CYP11B1CYP11B2ALDH1A1
SCHEMBL13425071 0.71 BRD4 (0.36) ALDH1A1
SCHEMBL3435529 0.70 CYP11B1 (0.38) NR3C2MMP12CYP11B1CYP11B2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137616-B Antibacterial agents comprising pyrazino [2,3-b ] [1,4] oxazin-3-ones or related ring systems 葛兰素史克知识产权开发有限公司 2020-06-26 CN disclosed
US-10683307-B2 Compounds for use in antibacterial applications GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-06-16 US disclosed
US-10683307-B2 Compounds for use in antibacterial applications GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-06-16 US disclosed
US-20190270755-A1 COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-09-05 US disclosed
US-20190270755-A1 COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-09-05 US disclosed
US-10364254-B2 Compounds for use in antibacterial applications GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-07-30 US disclosed
US-10364254-B2 Compounds for use in antibacterial applications GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-07-30 US disclosed
US-20190031680-A1 COMPOUNDS FOR US IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-31 US disclosed
US-20190031680-A1 COMPOUNDS FOR US IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-31 US disclosed
WO-2017029602-A2 COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-02-23 WO disclosed
EP-2041145-B1 AZATRICYCLIC COMPOUNDS AND THEIR USE GLAXO GROUP LTD (GB) 2010-10-27 EP disclosed
US-20100197679-A1 COMPOUNDS GLAXO GROUP LIMITED 2010-08-05 US disclosed
US-20100197679-A1 COMPOUNDS GLAXO GROUP LIMITED 2010-08-05 US disclosed
US-20100004230-A1 AZATRICYCLIC COMPOUNDS AND THEIR USE GLAXO GROUP LIMITED (GB) 2010-01-07 US disclosed
US-20100004230-A1 AZATRICYCLIC COMPOUNDS AND THEIR USE GLAXO GROUP LIMITED (GB) 2010-01-07 US disclosed
US-20090270374-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES GLAXO GROUP LIMITED (GB) 2009-10-29 US disclosed
US-20090270374-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES GLAXO GROUP LIMITED (GB) 2009-10-29 US disclosed
WO-2008128961-A1 COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-10-30 WO disclosed
WO-2008009700-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES GLAXO GROUP LIMITED (GB) 2008-01-24 WO disclosed
WO-2008003690-A1 AZATRICYCLIC COMPOUNDS AND THEIR USE GLAXO GROUP LIMITED (GB) 2008-01-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10683307-B2 Compounds for use in antibacterial applications MRPL21, CFTR, NRDC NR3C2 4671/4885MMP12 349/4885NR3C1 4853/4885
US-20190270755-A1 COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS MRPL21, CFTR, NRDC NR3C2 4671/4885MMP12 349/4885NR3C1 4853/4885
US-20100197679-A1 COMPOUNDS NRDC, MRPL21, NISCH NR3C2 3865/4885MMP12 1966/4885NR3C1 4105/4885
US-20100004230-A1 AZATRICYCLIC COMPOUNDS AND THEIR USE AADAC, AZI2, NNMT NR3C2 1149/4885MMP12 848/4885NR3C1 792/4885
US-20190031680-A1 COMPOUNDS FOR US IN ANTIBACTERIAL APPLICATIONS CFTR, MRPL21, CLPP NR3C2 4727/4885MMP12 602/4885NR3C1 4843/4885
US-20090270374-A1 DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES ETFA, NQO2, GNAQ NR3C2 3450/4885MMP12 2530/4885NR3C1 4399/4885
US-10364254-B2 Compounds for use in antibacterial applications MRPL21, CFTR, NRDC NR3C2 4671/4885MMP12 349/4885NR3C1 4853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.