Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882519 | 0.91 | MAT2A (0.45) | MAT2ANOTUMJAK2TYK2MAPT | |
| SCHEMBL4877684 | 0.82 | MAT2A (0.39) | MAT2AJAK2TYK2SMN1; SMN2MAPT | |
| SCHEMBL4487964 | 0.74 | JAK2 (0.40) | MAT2ANOTUMJAK2TYK2MAPT | |
| SCHEMBL13788904 | 0.72 | MAT2A (0.42) | MAT2ANOTUMSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4497287 | 0.71 | HTR2A (0.36) | MAT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4261005 | 0.71 | HRH3 (0.35) | MAT2AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL3986451 | 0.70 | JAK2 (0.36) | MAT2AJAK2TYK2SMN1; SMN2NPSR1 | |
| SCHEMBL3989631 | 0.70 | JAK2 (0.39) | MAT2AJAK2TYK2MAPK1KAT6A | |
| SCHEMBL3989442 | 0.67 | NPBWR1 (0.41) | JAK2TYK2SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4501812 | 0.66 | TYK2 (0.43) | MAT2ANOTUMJAK2TYK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | claimed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | MAT2A 4013/4885NOTUM 1116/4885JAK2 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.