Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882430 | 0.91 | MAT2A (0.46) | MAT2AJAK2TYK2MAPK1NPC1 | |
| SCHEMBL4877684 | 0.86 | MAT2A (0.39) | MAT2AJAK2TYK2MAPK1POLB | |
| SCHEMBL4487964 | 0.83 | JAK2 (0.40) | MAT2AJAK2TYK2MAPK1NPC1 | |
| SCHEMBL3989631 | 0.78 | JAK2 (0.39) | MAT2AJAK2TYK2MAPK1NPC1 | |
| SCHEMBL3986451 | 0.78 | JAK2 (0.36) | MAT2AJAK2TYK2POLBNPSR1 | |
| SCHEMBL4261005 | 0.75 | HRH3 (0.35) | MAT2AKAT6ATP53HTTKDM4E | |
| SCHEMBL4497287 | 0.75 | HTR2A (0.36) | MAT2AKDM4EALDH1A1 | |
| SCHEMBL3989442 | 0.75 | NPBWR1 (0.41) | JAK2TYK2MAPK1MAPTTP53 | |
| SCHEMBL13788904 | 0.74 | MAT2A (0.42) | MAT2AMAPK1NPC1NOTUMMAPT | |
| SCHEMBL4501812 | 0.72 | TYK2 (0.43) | MAT2AJAK2TYK2MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | claimed |
| EP-1848711-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2006089060-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-08-24 | — | — | WO | claimed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | MAT2A 4013/4885JAK2 3907/4885TYK2 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.