Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13790034 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL13790186 | 0.79 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTHTTTDP1 | |
| SCHEMBL828937 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL829031 | 0.75 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTHTTTDP1 | |
| SCHEMBL2394763 | 0.73 | MEN1 (0.54) | ALDH1A1GAAHTTMEN1CYP1A2 | |
| SCHEMBL830332 | 0.71 | KMO (0.49) | ALDH1A1MAPTHTTKDM4EL3MBTL1 | |
| SCHEMBL829038 | 0.70 | NPC1 (0.42) | ALDH1A1LMNAMAPTTDP1MEN1 | |
| SCHEMBL2396155 | 0.70 | PTPN1 (0.51) | ALDH1A1MAPTMEN1CYP1A2CYP2C19 | |
| SCHEMBL2398284 | 0.69 | RNASEH1 (0.41) | ALDH1A1GAAMAPTHTTNPC1 | |
| SCHEMBL2393053 | 0.69 | MEN1 (0.52) | ALDH1A1GAAMAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170830-A1 | Tricyclic Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | MERCK SHARP & DOHME CORP. | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170830-A1 | Tricyclic Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | BACE1, BACE2, PSEN1 | ALDH1A1 2151/4885LMNA 812/4885GAA 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.