Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394763 | 0.96 | MEN1 (0.54) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL2394945 | 0.91 | RAB9A (0.51) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL2394947 | 0.86 | RAB9A (0.52) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL2393644 | 0.86 | NPC1 (0.50) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL2393108 | 0.84 | KMT2A (0.59) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL830021 | 0.84 | KMO (0.42) | MEN1KMT2ACNR1CNR2NPC1 | |
| SCHEMBL2392613 | 0.83 | CPT2 (0.45) | MEN1KMT2ANPC1RAB9ATP53 | |
| SCHEMBL2394623 | 0.83 | RARA (0.48) | KMT2ANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2396155 | 0.82 | PTPN1 (0.51) | MEN1KMT2AHDAC3HDAC11HDAC8 | |
| SCHEMBL2396270 | 0.82 | HCAR3 (0.56) | DEGS1NPC1RAB9ARARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861640-B2 | Medicament for treatment of Alzheimer's disease | KEMPHYS LTD. (JP) | 2018-01-09 | — | — | US | claimed |
| US-20160206624-A1 | MEDICAMENT FOR TREATMENT OF ALZHEIMER'S DISEASE | KEMPHYS LTD. (JP) | 2016-07-21 | — | — | US | claimed |
| US-9861640-B2 | Medicament for treatment of Alzheimer's disease | KEMPHYS LTD. (JP) | 2018-01-09 | — | — | US | disclosed |
| US-20160206624-A1 | MEDICAMENT FOR TREATMENT OF ALZHEIMER'S DISEASE | KEMPHYS LTD. (JP) | 2016-07-21 | — | — | US | disclosed |
| EP-2189443-B1 | TRICYCLIC AMIDE COMPOUND | RES FOUND ITSUU LAB (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RXRA, RXRB, RXRG | MEN1 3029/4885KMT2A 1560/4885HDAC3 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.