Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | GOT1 | P17174 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176798 | 0.90 | PKM (0.43) | TRPV1MTNR1AMTNR1BGOT1ACACB | |
| SCHEMBL5177928 | 0.84 | KDM4E (0.39) | KDM4ETRPV1GOT1ACACBCDK2 | |
| SCHEMBL3882526 | 0.81 | NLRP3 (0.46) | ACACBLTA4HEPHX2CDK2KMT2A | |
| SCHEMBL1378534 | 0.79 | PPARD (0.41) | KDM4ETRPV1MTNR1AMTNR1BGOT1 | |
| SCHEMBL1383911 | 0.79 | KDM4E (0.41) | KDM4ETRPV1MTNR1AMTNR1BGOT1 | |
| SCHEMBL1380488 | 0.79 | GOT1 (0.43) | KDM4ETRPV1MTNR1AMTNR1BGOT1 | |
| SCHEMBL1377718 | 0.77 | KDM4E (0.39) | KDM4ETRPV1GOT1ACACBCDK2 | |
| SCHEMBL5175332 | 0.75 | PKM (0.42) | KDM4ETRPV1GOT1ACACBKMT2A | |
| SCHEMBL1379245 | 0.73 | KDM4E (0.50) | KDM4ETRPV1MTNR1AMTNR1BLTA4H | |
| SCHEMBL3874229 | 0.73 | TRPV1 (0.44) | KDM4ETRPV1MTNR1AMTNR1BACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4629106-B2 | — | — | 2011-02-09 | — | — | JP | claimed |
| JP-2008509947-A | — | — | 2008-04-03 | — | — | JP | claimed |
| EP-1781608-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-09 | — | — | EP | claimed |
| WO-2006018174-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | claimed |