Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GOT1 | P17174 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378534 | 0.88 | PPARD (0.41) | GOT1CDK2KDM4ETRPV1MTNR1A | |
| SCHEMBL1379245 | 0.81 | KDM4E (0.50) | KDM4ETRPV1MTNR1AMTNR1BTSHR | |
| SCHEMBL1378359 | 0.79 | PPARD (0.43) | CDK2KDM4ETSHR | |
| SCHEMBL1383911 | 0.79 | KDM4E (0.41) | GOT1CDK2KDM4ETRPV1MTNR1A | |
| SCHEMBL1379036 | 0.79 | KDM4E (0.41) | GOT1CDK2KDM4ETRPV1MEN1 | |
| SCHEMBL1377718 | 0.78 | KDM4E (0.39) | GOT1CDK2KDM4ETRPV1MMP2 | |
| SCHEMBL5177050 | 0.77 | PKM (0.44) | GOT1TRPV1MAPTMEN1KMT2A | |
| SCHEMBL5176046 | 0.76 | PKM (0.42) | GOT1TRPV1MAPTMEN1KMT2A | |
| SCHEMBL5177928 | 0.76 | KDM4E (0.39) | GOT1CDK2KDM4ETRPV1TSHR | |
| SCHEMBL5177101 | 0.74 | PPARD (0.36) | GOT1CDK2KDM4ETRPV1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4629106-B2 | — | — | 2011-02-09 | — | — | JP | claimed |
| JP-2008509947-A | — | — | 2008-04-03 | — | — | JP | claimed |
| EP-1781608-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-09 | — | — | EP | claimed |
| WO-2006018174-A1 | INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | claimed |