Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CDC25B | P30305 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556071 | 0.66 | TDP1 (0.40) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL1553785 | 0.65 | MAOB (0.42) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL4347020 | 0.63 | ALOX15 (0.42) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL4347018 | 0.63 | ALOX15 (0.42) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL3098842 | 0.62 | CYP19A1 (0.38) | PKMTSHRMAOBMEN1KMT2A | |
| SCHEMBL2512510 | 0.61 | PKM (0.36) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL15101248 | 0.60 | ALDH1A1 (0.41) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL19754922 | 0.58 | TDP1 (0.63) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL30320031 | 0.58 | TDP1 (0.63) | PKMTSHRTDP1ALOX15MAOA | |
| SCHEMBL12691224 | 0.58 | TDP1 (0.63) | PKMTSHRTDP1ALOX15MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4658477-B2 | — | — | 2011-03-23 | — | — | JP | claimed |
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | claimed |
| JP-2005516046-A | — | — | 2005-06-02 | — | — | JP | claimed |
| EP-1534286-A1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | Rigel Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | claimed |
| WO-2004014382-A1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | RIGEL PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | claimed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | claimed |
| EP-1951261-A4 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | RIGEL PHARMACEUTICALS INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1951261-A2 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007053844-A2 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |