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SCHEMBL6894684

SCHEMBL6894684

O=C(ON1CCC[C@H]1C(=O)ON1CCC[C@@H]1C(=O)OC(=O)[C@H]1CCCN1)[C@@H]1CCCN1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 12/20 0.38
▸ DPP8 Q6V1X1 5/20 0.38
▸ DPP9 Q86TI2 4/20 0.38
▸ FAP Q12884 1/20 0.38
▸ DPP7 Q9UHL4 1/20 0.38
▸ ANPEP P15144 1/20 0.32
▸ NOS2 P35228 2/20 0.31
▸ NOS3 P29474 1/20 0.31
▸ NOS1 P29475 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8941804 0.85 DPP4 (0.40) DPP4DPP8DPP9FAPDPP7
SCHEMBL137918 0.82 DPP4 (0.34) DPP4DPP8DPP9FAPDPP7
SCHEMBL10667177 0.79 DPP4 (0.41) DPP4DPP8DPP9FAPDPP7
SCHEMBL139232 0.79 DPP4 (0.35) DPP4DPP8DPP9FAPDPP7
SCHEMBL138094 0.78 DPP4 (0.38) DPP4DPP8DPP9FAPDPP7
SCHEMBL6859669 0.78 NOS2 (0.46) DPP4DPP8DPP9FAPDPP7
SCHEMBL995604 0.78 NOS2 (0.46) DPP4DPP8DPP9FAPDPP7
SCHEMBL146828 0.78 NOS2 (0.46) DPP4DPP8DPP9FAPDPP7
SCHEMBL9737609 0.74 NOS2 (0.43) DPP4DPP8DPP9FAPDPP7
SCHEMBL15323669 0.74 DPP4 (0.30) DPP4DPP8DPP9FAPDPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1384074-A2 METHODS FOR THE DIAGNOSIS AND TREATMENT OF BONE DISORDERS Metabometrix Limited (GB) 2004-01-28 — — EP disclosed
WO-2002086502-A2 METHODS FOR THE DIAGNOSIS AND TREATMENT OF BONE DISORDERS METABOMETRIX LIMITED (GB) 2002-10-31 — — WO disclosed